Asthma in Childhood

IL-23 Gene and Protein Expression in Childhood Asthma

Background: Asthma is the chronic inflammation of airways characterized by eosinophilic infiltration, mucus overproduction, airway hyper-responsiveness and airway remodeling. These changes are induced mostly by cytokines which are produced by T helper (Th) 2 cells. Recently, the role of interleukin-23 (IL-23) in the pathogenesis of adultallergic asthma has been studied. Objective: To explore IL...

Dermatophagoides in childhood asthma.

Monitoring asthma in childhood.

The goal of asthma treatment is to obtain clinical control and reduce future risks to the patient. However, to date there is limited evidence on how to monitor patients with asthma. Childhood asthma introduces specific challenges in terms of deciding what, when, how often, by whom and in whom different assessments of asthma should be performed. The age of the child, the fluctuating course of as...

Asthma in childhood.

Management decisions for pediatric asthma (in patients younger than 12 years of age) based on extrapolation from available evidence in adolescents and adults (age 12 years and older) is common but rarely appropriate. This article addresses the disparity in response between the two age groups, presents the available pediatric evidence, and highlights the important areas in which further research...

Allergic asthma in childhood.

Asthma is defined as a disease of the respiratory passages characterized by dyspnoea of an obstructive type which is predominantly expiratory, reversible at least partially, and of varying severity and duration (Meneely et al., 1962). The anatomical and biochemical basis of the bronchial obstruction has been reviewed by Middleton (1959). In the present review emphasis is put on the allergic asp...